A nonaqueous, extrudable composition includes at least one thermoplasticpolymer in an amount of more than 20wt% of the whole composition and tobacco. An extruded bioactive product in theform of a sheet can be made by extruding or hotmelt shaping a nonaqueous composition comprising at least one thermoplasticpolymer and a bioactive agent, the sheet being solublein a user's mouth and resulting in sustained release of bioactive to the user.The sheet can be in a form that may be placed in contactwith the mucosa of the user, and have an average dissolution time of 5 to 50minutes for delivering the bioactive to the user.