Embodiments provide a method and system for using a reconstructed or virtual reference point for electrocardiogram (ECG) measurements, allowing for the removal of the common reference point required in conventional ECG systems. Embodiments allow for either referencing measurements back to a reference previously digitized and reconstructed in the analog domain or to compare the measurements to a virtual reference. These calculations can be performed at the measurement site or remotely. Vector calculations can be made in either the analog or digital domains. A secondary means of measuring common mode noise (or rejection) injected into the ECG may be provided to ensure proper functioning in the presence of large common mode noise. These secondary measurements may be used to phase-align segments of the ECG vectors or as means to improve the common mode noise capabilities.
