The present application discloses the use of a polyurethane material in the preparation of a latex product, wherein the polyurethane material comprises a waterborne polyurethane and nano-silver. The polyurethane material of the present application is made of a combination of a waterborne polyurethane and nano-silver, which gives rise to the said latex products not only having a broad spectrum of antimicrobial activity including inactivating HIV-1 and HSV, but also having the ability to inactivate the microorganism in a short time.