HELLERBRAND, KLAUS,SIEDLER, MICHAEL,SCHUETZ, ANDREAS,POMPE, CORNELIUS,FRIESS, WOLFGANG
申请号：
DK05751734
公开号：
DK1763374T3
申请日:
2005.06.09
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
An in-situ-hardening paste, containing an organic or inorganic filling material, a biodegradable polymer and a water soluble polymeric plasticizer was developed as a delivery system for an active agent with scaffold properties in the filed of tissue regeneration. The hardened paste is sufficient mechanical stable to can be used as bone and cartilage replacement matrix. All components are full biocompatible, preferably bioresorbable and certified for parenteral application. The sustained release of peptides and proteins can be modulated by the composition and process design. The invention encompasses a pharmaceutical composition comprising the paste of the invention and relates to the use of said paste for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the paste of the invention.
