In some aspects, the present invention provides cellular reactive campastatin analogues and compositions comprising cel responsive campastatin analogues.In some aspects, the present invention further provides methods for the use of cellular reactive campastatin analogues, for example, for the treatment of complement mediated disorders； for example, for inhibiting complement mediated damage to cells, tissues or organs.In some aspects, the present invention provides long-acting campastatin analogues and compositions containing long-acting campastatin analogues.In some aspects, the present invention also provides a method of using long-acting campastatin analogues, for example, for treating complement mediated disorders； for example, for inhibiting complement mediated damage to cells, tissues or organs.In some aspects, the present invention provides targeted and compositions containing targeted campastatin analogues.In some aspects, the present invention also provides methods for the use of targeted campastatin analogues, for example, for the treatment of complement mediated disorders； for example, for the suppression of complement mediated damage to cells, tissues or organs.在某些方面，本發明提供了細胞反應性坎普他汀類似物和包含細胞反應性坎普他汀類似物的組合物。在某些方面，本發明進一步提供了使用細胞反應性坎普他汀類似物的方法，例如，治療補體介導的障礙；例如，用於抑制對細胞、組織或器官的補體介導的損傷。在某些方面，本發明提供了長效坎普他汀類似物和包含長效坎普他汀類似物的組合物。在某些方面，本發明另外提供了使用長效坎普他汀類似物的方法，例如，用於治療補體介導的障礙；例如，用於抑制對細胞、組織或器官的補體介導的損傷。在某些方面，本發明提供了靶向坎普他汀類似物和包含靶向坎普他汀類似物的組合物。在某些方面，本發明另外提供了使用靶向坎普他汀類似物的方法，例如，用於治療補體介導的障礙；例如，用於抑制對細胞、組織或器官的補體介導的損傷。
