Cellular reactive, long-acting or targeted campastatin analogues and related compositions and methods

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专利权人:

APELLIS PHARMACEUTICALS, INC.;阿佩利斯制药公司;阿佩利斯製藥公司

发明人:

FRANCOIS, Cedric,塞德里克．弗朗索瓦,DESCHATELETS, Pascal,帕斯卡尔．德沙特莱,帕斯卡爾．德沙特萊

申请号：

MOJ004027

公开号：

MOJ004027B

申请日:

2020.02.17

申请国别(地区):

MO

年份:

2020

代理人:

摘要：

In some aspects, the present invention provides cellular reactive campastatin analogues and compositions comprising cel responsive campastatin analogues.In some aspects, the present invention further provides methods for the use of cellular reactive campastatin analogues, for example, for the treatment of complement mediated disorders； for example, for inhibiting complement mediated damage to cells, tissues or organs.In some aspects, the present invention provides long-acting campastatin analogues and compositions containing long-acting campastatin analogues.In some aspects, the present invention also provides a method of using long-acting campastatin analogues, for example, for treating complement mediated disorders； for example, for inhibiting complement mediated damage to cells, tissues or organs.In some aspects, the present invention provides targeted and compositions containing targeted campastatin analogues.In some aspects, the present invention also provides methods for the use of targeted campastatin analogues, for example, for the treatment of complement mediated disorders； for example, for the suppression of complement mediated damage to cells, tissues or organs.在某些方面，本發明提供了細胞反應性坎普他汀類似物和包含細胞反應性坎普他汀類似物的組合物。在某些方面，本發明進一步提供了使用細胞反應性坎普他汀類似物的方法，例如，治療補體介導的障礙；例如，用於抑制對細胞、組織或器官的補體介導的損傷。在某些方面，本發明提供了長效坎普他汀類似物和包含長效坎普他汀類似物的組合物。在某些方面，本發明另外提供了使用長效坎普他汀類似物的方法，例如，用於治療補體介導的障礙；例如，用於抑制對細胞、組織或器官的補體介導的損傷。在某些方面，本發明提供了靶向坎普他汀類似物和包含靶向坎普他汀類似物的組合物。在某些方面，本發明另外提供了使用靶向坎普他汀類似物的方法，例如，用於治療補體介導的障礙；例如，用於抑制對細胞、組織或器官的補體介導的損傷。

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/