Provided herein is a nano drug composition for the treatment of cancer including 0.125-0.5 mg of methylglyoxal as conjugated to nanoparticles of chitosan, its derivatives, or other polymers 25-100 mg of ascorbic acid 75-300 mg of creatine and 0.125-0.5 mg of melatonin, wherein all constituents are meant for each kg of body weight.