The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.本發明提供治療肥胖症及超重、糖尿病及其他相關代謝病症之物質及方法。具體而言,本發明提供在該等方法中有效之新穎升糖素類似物肽。該等肽可藉由與人類升糖素相比增加對GLP-1受體之選擇性調介其效應。