The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.本發明提供用於治療肥胖症及超重、糖尿病及其他相關的代謝障礙之材料及方法。詳言之,本發明提供在此類方法中有效之新穎醯化昇糖素類似物肽。相較於人類昇糖素,該等肽可藉由對於GLP-1受體具有提高的選擇率來介導其效果。