Systems and methods of processing data generated using multi-gain detectors are disclosed. These systems and methods include separate gain images and separate offset images associated with each dynamic range of a multi-gain detector. These images are applied to multi-gain raw data to generate multi-gain corrected data. Some embodiments of the invention further include systems and methods of generating and using a multi-gain look-up table configured for generating viewable data from multi-gain corrected data. Some embodiments of the invention further include systems and methods of generating a global gain ratio for converting multi-gain data to non-multi-gain data.
