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PHARMACEUTICAL COMPOSITION PARTICLES, ORALLY DISINTEGRATING PREPARATION CONTAINING SAME, AND METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITION PARTICLES
专利权人:
ZENSEI PHARMACEUTICAL INDUSTRIES CO.,LTD.;NIPRO CORPORATION
发明人:
Tomohiro HAYASHIDA,Yohei HOASHI,Shin IJITSU,Yoshio NAKANO,Junji YAMAZAKI,Katsuhisa INOUE,Atsushi AIZAWA
申请号:
US16641014
公开号:
US20200214985A1
申请日:
2018.08.20
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Pharmaceutical composition particle capable of masking an unpalatable taste and improvement in dissolution properties, an orally disintegrating tablet containing the pharmaceutical composition particle, and a method for manufacturing a pharmaceutical composition particle. The pharmaceutical composition particle includes a core particle containing a drug and a water-soluble gelling swelling substance; and an outer layer which contains a water-insoluble substance and constitutes a coating provided on the outer side of the core particle. The method for manufacturing includes: pulverizing a water-soluble gelling swelling substance to have an average particle diameter of 15 μm or less; a core particle manufacturing step of mixing the water-soluble gelling swelling substance pulverized and a drug to manufacture a core particle; and an outer layer formation step of coating the core particle with a water-insoluble substance on the outer side of the core particle.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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