PRODUITS DE DIAGNOSTIC PAR RESONANCE MAGNETIQUE DE MALADIES ONCOLOGIQUES CONTENANT UN ACIDE 2-AMINO-2-METHYLPROPIONIQUE DEUTERE ET/OU UN ACIDE 2-(N-METHYLAMINO)-2-METHYLPROPIONIQUE DEUTERE AINSI QUE METHODE DIAGNOSTIQUE UTILISANT CE PRODUIT
LESIV, ALEKSEI VALERIEVICH,IVASHKIN, PAVEL EVGENIEVICH,GULYAEV, MIKHAIL VLADIMIROVICH,DOROFEEVA, EVGENIYA OLEGOVNA,KOSENKOV, ALEKSEI VIKTOROVICH,KISELEVSKY, MIKHAIL VALENTINOVICH,POLSHAKOV, VLADIMIR I
申请号：
CA3083111
公开号：
CA3083111A1
申请日:
2017.11.21
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to medicine, particularly to agents for magnetic resonance diagnostics for oncological diseases. Developed for this purpose are a diagnostic preparation and a diagnostic method based on using said diagnostic preparation, in which a deuterated derivative of 2-amino-2-methylpropionic acid or 2-(N-methylamino)-2-methylpropionic acid and/or a pharmaceutically acceptable salt thereof, or a mixture of at least two deuterated derivatives of 2-amino-2-methylpropionic acid and/or 2-(N-methylamino)-2-methylpropionic acid and/or the pharmaceutically acceptable salt thereof is used as said preparation. The method according to the invention includes conducting magnetic resonance imaging and/or magnetic resonance spectroscopy on deuterium nuclei at a time after administration of the diagnostic preparation sufficient for the diagnostic preparation to accumulate in the tumor tissue of a subject in order to produce a magnetic resonance image and/or a magnetic resonance spectrum accordingly. The proposed method enables a highly informed diagnosis of oncological diseases.
