Jennifer Brogdon,Saar Gill,Carl H. June,Michael D. Kalos,Andreas Loew,John Scholler
申请号：
US15400096
公开号：
US20170183415A1
申请日:
2017.01.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.
