FORMULATION POUR UN ANTICORPS ANTI-.ALPHA.4.BETA.7

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专利权人:

INC.;MILLENNIUM PHARMACEUTICALS

发明人:

DILUZIO, WILLOW,NGUYEN, PHUONG M.,VARGA, CSANAD M.,PALANIAPPAN, VAITHIANATHAN,BROWN, JASON,FOX, IRVING H.,SCHOLZ, CATHERINE,JENKINS, HELEN,ROSARIO, MARIA

申请号：

CA2834900

公开号：

CA2834900A1

申请日:

2012.05.02

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

Antibody formulations are described comprising a mixture of an anti-a4ß7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-a4ß7 antibody in vivo.

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