The purpose of the present invention is to provide a production method of a nasal drop composition suitable for the treatment or prevention of disease or symptoms in the nasal cavity, and a nasal drop composition obtained by said production method. This production method of a nasal drop composition is characterized by involving a mixing step for mixing earthworm castings and water, and a recovery step for obtaining a liquid by recovering vaporized water generated from the mixture obtained in the mixing step； this nasal drop composition is obtained by said production method. In the mixing step, it is favorable to further mix organic matter in addition to the earthworm castings and the water.
