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URACYL SPIROOXETANE NUCLEOSIDES
专利权人:
MEDIVIR AB
发明人:
JONCKERS, TIM HUGO MARIA,RABOISSON, PIERRE JEAN-MARIE,VANDYCK, KOEN,VAN HOOF, STEVEN MAURICE PAULA,HU, LILI,TAHRI, ABDELLAH
申请号:
CA2760329
公开号:
CA2760329C
申请日:
2010.05.11
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Compounds of the formula (I) including any possible stereoisomers thereof,wherein: R4 is a monophosphate,diphosphate or triphosphate ester or R4 is formula (II) or formula (III), R7is optionally substituted phenyl, optionally substitutednaphthyl, or optionally substituted indolyl R8 and R8 are hydrogen, C1-C6alkyl, benzyl, or phenyl or R8 and R8 form C3-C7cycloalkylR9 is C1-C10alkyl, C3-C7cycloalkyl, phenyl or phenyl-C1-C6alkyl, wherein thephenyl moiety in phenyl or phenyl-C1--C6alkylis optionally substituted or a pharmaceutically acceptable salt or solvatethereof pharmaceutical formulations and the useof compounds I as HCV inhibitors.
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