The disclosed apparatus, systems and methods relate to predicting, screening, and monitoring for delirium. Systems and methods may include receiving one or more signals from one or more sensing devices； processing the one or more signals to extract one or more features from the one or more signals； analyzing the one or more features to determine one or more values for each of the one or more features； comparing at least one of the one or more values or a measure based on at least one of the one or more values to a threshold； determining a presence, absence, or likelihood of the subsequent development of delirium for a patient based on the comparison； and outputting an indication of the presence, absence, or likelihood of the subsequent development of delirium for the patient.
