In one aspect, the present invention provides isolated novel peptides that canbe used to modulate innate immunity in a subject. and/or for the treatment of animmune-related disorder, including treating and preventing infection by modulatinginnate immunity. Also provided are an agent reactive with the peptide, a pharmaceuticalcomposition that includes the peptide, an isolated nucleic acid molecule encodingthe peptide, a recombinant nucleic acid construct that includes the nucleicacid molecule, at least one host cell comprising the recombinant nucleic acidconstruct, and a method of producing the peptide using the host cell. The presentinvention further provides a method for treating and/or preventing infectionin a subject by administering the peptide of the invention to the subject, therebymodulating innate immunity in the subject. Additionally, the present inventionprovides a method for predicting whether a subject would be responsive to treatmentwith a peptide of the invention.
