The U.S.A. as represented by the Secretary; Department of Health and Human Services
发明人:
LIU, Zhibo,CHEN, Xiaoyuan
申请号：
EP16787230
公开号：
EP3288952A4
申请日:
2016.04.29
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Disclosed are boron mimics of amino acids which are compounds, salts, solvates, or stereoisomers of the Formula (I): wherein A, R.1, R2, and R3 are defined herein, and processes for the preparation of the compounds, salts, solvates, or stereoisomers. The compounds, salts, solvates, or stereoisomers of Formula (I) may be used in boron neutron capture therapy. The compounds, salts, solvates, or stereoisomers of Formula (I) with at least one fluorine being, 18F are useful for imaging tumors using positron emission tomography and for evaluating the treatment potential of anti-cancer drugs.
