PROBLEM TO BE SOLVED: To provide a method for screening a compound which inhibits TACC3 activity, in which TACC3 is a target.SOLUTION: Provided is a method for screening a compound or the like, in which connection between amino acid fragments of amino acid sequence number 593-838 of TACC3 and TOGp having amino acid sequence number of 1890-2032, the amino acid fragments including the amino acid sequence number 593-838 of the TACC3 are recombinant protein including amino acid fragments formed of amino acid sequence number 593-838 of the TACC3, the amino acid fragments including amino acid sequence number 1890-2032 of the TOGp are recombinant protein including the amino acid fragments formed of the amino acid sequence number 1890-2032 of the TOGp, in which, at least one of recombinant protein includes a sequence required for detection.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2016,JPO&INPIT【課題】TACC3を標的として、TACC3活性を阻害する化合物をスクリーニングする方法を提供する。【解決手段】TACC3のアミノ酸配列番号593~838のアミノ酸断片とTOGpのアミノ酸配列番号1890~2032との結合を指標として化合物等をスクリーニングする方法であって、TACC3のアミノ酸配列番号593~838を含むアミノ酸断片がTACC3のアミノ酸配列番号593~838からなるアミノ酸断片を含む組換えタンパク質であり、TOGpのアミノ酸配列番号1890~2032を含むアミノ酸断片が、TOGpのアミノ酸配列番号1890~2032からなるアミノ酸断片を含む組換えタンパク質であり、少なくともいずれか一方の前記組換えタンパク質が検出に必要な配列を含む化合物のスクリーニング方法。【選択図】図1
