GAUCHER BÉRANGÈRE,DANEL FRANCK HUBERT,TANG XIAOHU,XIE TONG,XU LIN
申请号：
IN6252/CHENP/2012
公开号：
IN2012CN06252A
申请日:
2012.07.16
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
23814242424241616161616166161614141414Compound of formula (I): wherein A1 represents O S or N R3 A2 represents CH O N R4 C(=O) or CH(O R4) A3 represents C Ccycloalkylene saturated and unsaturated 4 to 8 membered heterocyclodiyl with 1 2 or 3 heteroatoms selected from nitrogen oxygen and sulphur which group A3 is unsubstituted or substituted A4 represents C Calkylene C Calkenylene >C=O or a group selected from CHNH CHO and CHS being linked to the adjacent NR5 group via the carbon atom and G represents aryl or heteroaryl which is unsubstituted or substituted and R1 and R2 independently of one another represent hydrogen or a substituent selected from hydroxy halogen mercapto cyano nitro C Calkyl C Calkoxy C Calkylthio C Calkylcarbonyloxy C Calkylsulfonyloxy C Cheteroalkylcarbonyloxy C5 Cheterocyclylcarbonyloxy C Cheteroalkoxy wherein heteroalkyl heteroalkoxy groups or heterocyclyl comprise 1 2 or 3 heteroatoms selected from nitrogen oxygen and sulphur in which substituents the alkyl moieties are unsubstituted or further substituted R3 R4 and R5 independently of one another represent hydrogen or C Calkyl X1 and X2 independently of one another represent a nitrogen atom or CR2 with the proviso that at least one of Xl and X2 represents a nitrogen atom m is 1 and the (CH2)m moiety is optionally substituted by C Calkyl halogen carboxy hydroxy C Calkoxy C C alkylcarbonyloxy amino mono or di (C Calkyl)amino or acylamino n is 0 1 or 2 or pharmaceutically acceptable salt thereof are valuable for use as a medicament for the treatment of bacterial infections.
