XIAO, XIAO-YI,PATEL, DINISH V.,WARD, JOHN S.,BRAY, MARK R.,AGOSTON, GREGORY E.,TRESTON, ANTHONY M.
申请号：
ES06825267
公开号：
ES2535854T3
申请日:
2006.09.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I: ** Formula ** or its pharmaceutically acceptable derivatives or prodrugs, wherein: Rx and Ry are independently selected from the group consisting of -T-R3 and -L-Z-R3； Q 'is selected from the group consisting of -CR6' '>； = CR6' '- and, wherein said -CR6' '>； = CR6' '- can be a cis or trans double bond or mixtures thereof； R1 is -T- (Ring D)； Ring D is a 5-7 membered monocyclic ring or an 8-10 membered bicyclic ring selected from the group consisting of aryl and heteroaryl, said heteroaryl ring having 1-4 ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, in which each carbon of the replaceable ring of Ring D is independently substituted with oxo, -T-R5, or -VZ-R5, and each nitrogen of the replaceable ring of Ring D is independently substituted with -R4； T is a Valencia bond； Z is a C1-4 alkylidene chain； L is selected from the group consisting of -O-； -S-, -SO-, -SO2-, -N (R6) SO2-, -SO2N (R6) -, -N (R6) -, -CO-, -CO2-, - N (R6) CO-, -N (R6) C (O) O-, -N (R6) CON (R6) -, -N (R6) SO2N (R6) -, -N (R6) N (R6) -, -C (O) N (R6) -, -OC (O) N (R6) -, -C (R6) 2O-, - C (R6) 2-, -C (R6) 2SO-, -C (R6) 2SO2-, - C (R6) 2SO2N (R6) -, -C (R6) 2N (R6) -, -C (R6) 2N (R6) C (O) -, -C (R6) 2N (R6) C (O) O -, - C (R6)>； = NN (R6) -, -C (R6)>； = NO-, -C (R6) 2N (R6) N (R6) -, -C (R6) 2N (R6) SO2N (R6) -, and -C (R6) 2N (R6) CON (R6) -； R2 and R2 'are independently selected from the group consisting of -R and -TW-R6, or R2 and R2', taken together with their intermediate atoms, form an unsaturated or partially unsaturated 5-8 membered ring having 0- 3 ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, in which each carbon of the replaceable ring of said fused ring formed by R2 and R2 'is independently substituted with halo, oxo, -CN, -NO2, R7, or -V-R6, and each nitrogen of the replaceable ring of said ring formed by R2 and R2 'is independently substituted with -R4； R3 is selected from the
