THOMAS AICHER,KENNETH BARR,VLADIMIR SIMOV,WILLIAM THOMAS,PETER TOOGOOD,CHAD VAN HUIS
申请号：
MX2014013554
公开号：
MX2014013554A
申请日:
2013.05.03
申请国别(地区):
MX
年份:
2015
代理人:
摘要：
The invention provides bicyclic sulfone compounds, pharmaceutical compositions, methods of inhibiting RORy activity, reducing the amount of iL-17 in a subject, and treating immune disorders and inflammatory disorders using such bicyclic sulfone compounds. Another aspect of the invention provides a method of treating a subject suffering from a medical disorder. The method comprises administering to the subject a therapeutically effective amount of one or more bicyclic sulfone compounds described herein. In certain other embodiments, the disorder is rheumatoid arthritis.La invención proporciona compuestos de sulfona bicíclica, composiciones farmacéuticas, métodos para la inhibición de la actividad de ROR?, la reducción de la cantidad de IL-17 en un sujeto y el tratamiento de trastornos inmunes y trastornos inflamatorios mediante el uso de tales compuestos de sulfona bicíclica.
