WILSON, JAMES M.,TEPE, APRIL,TURNER, KEVIN,SIMS, JOSHUA JOYNER
申请号：
CA3091806
公开号：
CA3091806A1
申请日:
2019.02.27
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
A recombinant adeno-associated virus (rAAV) vector comprising an AAV capsid having a heterogeneous population of vp1 proteins, a heterogeneous population of vp2 protein and a heterogeneous population of vp3 proteins. The capsid contains modified amino acids as compared to the encoded VP 1 amino acid sequence, the capsid containing highly deamidated asparagine residues at asparagine - glycine pair, and further comprising multiple other, less deamidated asparagine and optionally glutamine residues. Methods of reducing deamidation in the AAV capsid of a rAAV are provided.
