THE REGENTS OF THE UNIVERSITY OF COLORADO; A BODYCORPORATE
发明人:
HODGES, ROBERT,JIANG, ZIQING
申请号：
EP09819768
公开号：
EP2346521A4
申请日:
2009.10.06
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
Disclosed herein are antimicrobial peptides with useful and/or superior properties such as specificity, resistance to degradation, antimicrobial activity, desirably low levels of hemolytic activity, and a therapeutic index against a broad range of microorganisms including gram-negative, gram-positive and acid-fast bacteria, fungi and other organisms. Also provided are pharmaceutical compositions comprising these peptides and methods of using such peptides to control microbial growth or to treat or reduce incidence of infections caused by such microorganisms. Also disclosed are peptides at least one or all amino acids in the D configuration. Compositions disclosed herein are useful in the treatment of bacterial, mycobacterial and/or fungal infections or for reducing microbial cell numbers or growth on surfaces or in materials.
