JOHNS, BRIAN ALVIN,KAWASUJI, TAKASHI,TAISHI, TERUHIKO,TAODA, YOSHIYUKI
申请号：
CA2606282
公开号：
CA2606282C
申请日:
2006.04.28
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Novel compounds of formula (I) shown below are provided, having anti-HIVactivity, particularly HIV integrase inhibitory activity, as well as processesfor theirpreparation and intermediates used therein, for potential use as anti-HIVdrugs.(see formula I)(whereinZ1 is NR4；R1 is hydrogen or lower alkyl；X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH,or lower alkylene or lower alkenylene in which the hetero atom group mayintervene；R2 is optionally substituted aryl；R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc；andR4 and Z2 part taken together forms a ring, to form a polycyclic compound,including e.g., a tricyclic or tetracyclic compound.)
