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DERIVE DE BENZOAZEPINE ET UTILISATION MEDICALE ASSOCIEE
专利权人:
LTD.;SANWA KAGAKU KENKYUSHO CO.
发明人:
KITAMOTO, KATSUNORI,KASUGAI, NOBUYOSHI,KATAOKA, HIROYO,OHSAWA, YASUSHI,KUNO, YUKA,FUJIEDA, HIROKI,SAKAI, KEITA,NAGANO, HIROKI,TAKAHASHI, NAOKI,IZUCHI, TORU,TAKEUCHI, MITSUAKI,KURUMAZUKA, DAISUKE,MIYAZ
申请号:
CA2889239
公开号:
CA2889239A1
申请日:
2013.12.26
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The objective of the present invention is to provide a compound which has V2 receptor agonistic activity. A pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (In general formula (I), R1 represents a group represented by formula (2) or the like; R2 represents a hydrogen atom or a lower alkyl group; R3 represents a lower alkyl group which may be substituted by 1-3 fluorine atoms, or a halogen atom; R4 represents a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group or the like (provided that these heterocyclic groups have at least one nitrogen atom and may be substituted by a lower alkyl group); and R5 represents a lower alkyl group, a halogen atom or the like.) (In formula (2), A represents a lower alkylene group which may be substituted by a lower alkyl group, or the like; R6 represents a hydrogen atom or the like; and R7 represents a hydroxyl group, an aromatic heterocyclic group which may be substituted by a lower alkyl group, a carbamoyl group or the like.)
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