PROBLEM TO BE SOLVED: To provide a therapeutic agent for S1P-mediated diseases such as diseases resulting from vascular constriction, fibrosis and respiratory diseases.SOLUTION: The invention provides compounds represented by the general formula (I-1). (In the formula, all the symbols are as described in the specification.)SELECTED DRAWING: None【課題】S1P2介在性疾患、例えば、血管の収縮に起因する疾患、線維症、呼吸器系疾患等の治療剤を提供する。【解決手段】一般式(I-1)(式中、すべての記号は明細書記載の通り。)で示される化合物。【選択図】なし