To provide a compound having potent human S1P2 antagonistic activity in order to develop a medicinal product useful for the treatment of S1P2-mediated diseases such as diseases caused by vasoconstriction, fibrosis, respiratory diseases and the like. The compound represented by the general formula (I) (wherein all symbols are as described in the description) is a potent human S1P2 antagonist by introducing a halogen atom or a haloalkyl group and a phenoxy group at a specific substitution position. Since it has activity, it can be a therapeutic agent for S1P2-mediated diseases such as diseases caused by vasoconstriction, fibrosis, respiratory diseases and the like.Ｓ１Ｐ２介在性疾患、例えば、血管の収縮に起因する疾患、線維症、呼吸器系疾患等の治療に有用な医薬品を開発するため、強力なヒトＳ１Ｐ２拮抗活性を有する化合物を提供すること。 一般式（Ｉ）（式中、すべての記号は明細書記載の通り。）で示される化合物は、ハロゲン原子またはハロアルキル基およびフェノキシ基を特定の置換位置に導入することによって、強力なヒトＳ１Ｐ２拮抗活性を有することから、Ｓ１Ｐ２介在性疾患、例えば、血管の収縮に起因する疾患、線維症、呼吸器系疾患等の治療剤となり得る。
