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METHODES DE PREPARATION DE FORMULATIONS OPHTALMIQUES ET LEURS UTILISATIONS
专利权人:
INC.;COGNOPTIX
发明人:
BHAGAT, HARESH,CAGLE, GERALD D.,SMITH, FRANCIS X.,HARTUNG, PAUL D.
申请号:
CA2928968
公开号:
CA2928968A1
申请日:
2014.10.30
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof. Values and preferred values of the variables in structural Formula (I) are described herein.
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