The present invention concerns a composition prepared from a combination ofnon .beta.-oxidizable fatty acid entities and a protein material, and the useof said composition for the preparation of a pharmaceutical or nutritionalcomposition for the prevention and/or treatment of insulin resistance,obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia,atherosclerosis, coronary heart disease, thrombosis, stenosis, secondarystenosis, myocardial infarction, stroke, elevated blood pressure, endothelialdysfunction, procoagulant state, polycystic ovary syndrome, the metabolicsyndrome, cancer, inflammatory disorders and proliferate skin disorders. Analternative embodiment of the invention includes oil in the composition. Thepresent invention also concerns an animal feed prepared from a combination ofa protein material and a compound comprising non .beta.-oxidizable fatty acidanalogues, the use of said feed for improving the body composition of ananimal, and a product produced from said animal.