Richard Béliveau,Michel Demeule,Christian Che,Anthony Regina
申请号：
US12601803
公开号：
US09365634B2
申请日:
2008.05.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Based on our identification of a polypeptide (Angiopep-7) that is efficiently transported to cells such as liver, lung, kidney, spleen, and muscle, the invention provides polypeptides, conjugates including the polypeptides, and methods for treating diseases associated with these cell types. Unlike other aprotinin related polypeptides identified herein (including Angiopep-3, Angiopep-4a Angiopep-4b Angiopep-5, and Angiopep-6) which efficiently cross the blood-brain barrier (BBB), Angiopep-7 is not efficiently transported across the BBB.
