BELIVEAU RICHARD,BELIVEAU Richard,DEMEULE MICHEL,DEMEULE Michel,CHE CHRISTIAN,CHE Christian,REGINA ANTHONY,REGINA Anthony
申请号：
SI200831246
公开号：
SI2164866T1
申请日:
2008.05.29
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
The invention provides aprotinin-like polypeptides for delivering agents conjugated thereto to tissues. Based on our identification of a polypeptide (Angiopep-7) that is efficiently transported to cells such as liver, lung, kidney, spleen, and muscle, the invention provides polypeptides, conjugates including the polypeptides, and methods for treating diseases associated with these cell types. Unlike other aprotinin related polypeptides identified herein (including Angiopep-3, Angiopep-4a Angiopep-4b Angiopep-5, and Angiopep-6) which efficiently cross the blood-brain barrier (BBB), Angiopep-7 is not efficiently transported across the BBB.
