SPIRO[3H-INDOLE-3,2-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS

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专利权人:

发明人:

Juergen RAMHARTER,Joachim BROEKER,Annika GILLE,Andreas GOLLNER,Manuel HENRY,Nina KERRES,Harald WEINSTABL

申请号：

US14831241

公开号：

US20160052938A1

申请日:

2015.08.20

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention encompasses compounds of formula (I)wherein the groups R1 to R7, A, V, W, X, Y, n, r and q are as defined herein, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.

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