ТАКЕУЧИ Жанет А. (US),Ли Линг (US),ХЕЙДЕЛЬБАУ Тод М. (US),ЧОУ Кен (US),КЕДЗИ Карен М. (US),ДЖИЛ Дэниел В. (US),ФАНГ Вэнкуй К. (US)
申请号：
RU2010141940/15
公开号：
RU2010141940A
申请日:
2009.03.24
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of treating pain, comprising administering to the mammal, if necessary, a pharmaceutical composition comprising a therapeutically effective dose of at least one compound having the structure:! ! where X is O, S, or NH； ! n and m are independently from each other from 1 to 5； ! each R1 and R2, independently of one another, is H, alkyl, cycloalkyl, aryl, alkenyl, alkynyl, halide, hydroxy, alkoxy, trifluoromethyl, —N (R6) 2, —CN, CO2R6, or —CH2OH； and! each R3, R4, R5 and R6, independently of one another, is H or lower alkyl； or a combination thereof, or their pharmaceutically acceptable salts, hydrates, solvates, crystalline forms, isomers, tautomers, enantiomers and diastereomers. ! 2. The method according to claim 1, where each R1 and R2 independently of one another is H, lower alkyl, fluoro, chloro, bromo, trifluoromethyl, hydroxy or methoxy. ! 3. The method according to claim 1, where X is S.! 4. The method according to claim 3, where each R1 and R2 independently of each other represents H, lower alkyl, fluoro, chloro, bromo, trifluoromethyl, hydroxy or methoxy. ! 5. The method according to claim 4, where the compound has the structure:! ! ! 6. The method according to claim 1, where X represents NH. ! 7. The method according to claim 6, where each R1 and R2 independently of each other represents H, lower alkyl, fluoro, chloro, bromo, trifluoromethyl, hydroxy or methoxy. ! 8. The method according to claim 7, where the connection has a structure! ! ! ! ! ! ! ! ! 9. The method according to claim 1, where X represents O.! 10. The method according to claim 9, where each R1 and R2 independently of one another is H, lower alkyl, fluoro, chloro, bromo, trifluoromethyl, hydroxy or methoxy. ! 11. The method according to claim 9, where the connection has a structure! ! ! ! 12. The method according to claim 1, where the pharmaceutical �1. Способ лечения боли, включающий введение млекопитающему в случае необходимости фармацевтической композиции, содержащей терапевт
