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METHODS FOR STABILIZING OXIDATIVELY UNSTABLE COMPOSITIONS
专利权人:
ИНК. (US);ДЖОНСОН ЭНД ДЖОНСОН ВИЖН КЭА
发明人:
МАХАДЕВАН Шивкумар (US),МОЛОК Фрэнк (US)
申请号:
RU2012125612/15
公开号:
RU2012125612A
申请日:
2012.06.19
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method for stabilizing an ophthalmic composition comprising an oxidatively unstable excipient, characterized in that said method comprises adding an effective amount of a stabilizing agent to the ophthalmic composition. The method according to claim 1, characterized in that the oxidatively unstable filler is selected from the group consisting of: cellulose derivatives, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hyaluronic acid, methyl cellulose, Dextran, gelatin, polyols, glycerol, polyethylene glycol polyethylene glycol polyisol povidone lanolin, mineral oil, paraffin, petrolatum, white ointment, white petrolatum, white wax and yellow wax. 3. The method according to claim 1, characterized in that the stabilizing agent is selected from the group consisting of silicon dioxide, a derivative of chitin, such as chitosan, cellulose, its derivatives, N, N, N ', N', N ”, N” hex (2-pyridyl) -1,3,5-tris (aminomethyl) benzene, diethylene triamine pentaacetic acid and salts of diethylene triamine pentaacetic acid. 4. The method according to claim 1, characterized in that the stabilizing agent is selected from the group consisting of diethylene triamine pentaacetic acid and salts of diethylene triamine pentaacetic acid. The method according to claim 1, characterized in that the effective amount of a stabilizing agent is from about 20 μmol / L to about 1000 μmol / L. The method according to claim 1, characterized in that the effective amount of a stabilizing agent is from about 100 μmol / L to about 600 μmol / L. The method according to claim 1, characterized in that the stabilizing agent is diethylene triamine pentaacetic acid. The method according to claim 1, excellent1. Способ стабилизации глазной композиции, включающей окислительно нестабильный наполнитель, отличающийся тем, что указанный способ включает добавление эффективного количества стабилизирующего средства в глазную композицию.2. Способ по п.1, отличающийся тем, что окислительно не
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