This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base (Form 7). This invention also relates to pharmaceutical compositions comprising Form 7, and to methods of using Form 7 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.本發明係關於(10R)-7-胺基-12-氟-2,10,16-三甲基-15-側氧基-10,15,16,17-四氫-2H-8,4-(亞甲橋)吡唑並[4,3-h][2,5,11]苯並氧二氮雜環十四烯(cyclotetradecine)-3-甲腈(洛拉替尼(lorlatinib))游離鹼的晶型(第七型)。本發明亦關於含第七型之醫藥組成物,及使用第七型及其組成物於治療哺乳動物之異常細胞生長諸如癌症的方法。
