The application provides formula (J) compound or its pharmaceutically acceptable salt, isomers, tautomer or mixture, and wherein n, m, R1, R2, R3, R4 and R5 are described in this application. The compound is phosphatidyl-inositol 3-kinase (PI3K) activity inhibitor, can treat the illness mediated by one or more kinds of PI3K hypotypes with what. The application also provides the pharmaceutical composition comprising formula (I) compound or its pharmaceutically acceptable salt, isomers, tautomer or mixture, and the method for the illness mediated using these compounds and composition treatment by one or more kinds of PI3K hypotypes.本申請提供式(J)化合物或者其藥學上可接受的鹽、異構體、互變異構體或混合物，其中n、m、R1、R2、R3、R4和R5描述在本申請中。所述化合物爲磷脂酰肌醇3-激酶(PI3K)活性抑制劑，可用於治療由一種或者多種PI3K亞型介導的病症。本申請還提供包含式(I)化合物或者其藥學上可接受的鹽、異構體、互變異構體或混合物的藥物組合物，以及使用這些化合物和組合物治療由一種或者多種PI3K亞型介導的病症的方法。
