RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
发明人:
Yoe-Sik BAE,Sung Kyun LEE
申请号：
US15065300
公开号：
US20160271114A1
申请日:
2016.03.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided are a composition for preventing or treating a bacterial infectious disease, comprising a phospholipase D2 (PLD2) inhibitor as an active ingredient and a method for treating the bacterial infectious disease using the same.Since the PLD2 inhibitor according to the present invention exhibits characteristics such as blocking of lung inflammation and liver inflammation, bactericidal activity through induction of NET production, effective maintenance of neutrophil mobility through the blocking of intracellular CXCR2 migration, and blocking of the production of inflammatory cytokines in bacterial infectious disease models, particularly, sepsis models, it is expected to be used as a therapeutic agent for sepsis or septic shock.
