Batches of recombinant adenovirus with altered terminal ends

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专利权人:

发明人:

Jerome H. H. V. Custers,Jort Vellinga

申请号：

US13794318

公开号：

US08932607B2

申请日:

2013.03.11

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Described is a composition comprising a plurality of recombinant adenovirus particles, being a recombinant human adenovirus of serotype 5, 26, 34, 35, 48, 49 or 50, or a recombinant simian adenovirus, characterized in that the genomes of essentially all adenovirus particles in the composition comprise as the 5′ terminal nucleotides the nucleotide sequence: CTATCTAT (nucleotides 1-8 of SEQ ID NO:7). Also described are methods to produce such compositions.

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