ABRAHAM BOUT;CRUCELL HOLLAND B.V.;MENZO JANS EMCO HAVENGA;RONALD VOGELS
发明人:
ABRAHAM BOUT,MENZO JANS EMCO HAVENGA,RONALD VOGELS
申请号：
IL21441311
公开号：
IL214413A
申请日:
2011.08.02
申请国别(地区):
IL
年份:
2014
代理人:
摘要：
The serotypes differ in their natural tropism. The adenovirus serotypes 2, 4, 5 and 7 all have a natural affiliation towards lung epithelia and other respiratory tissues. In contrast, serotypes 40 and 41 have a natural affiliation towards the gastrointestinal tract. The serotypes described above, differ in at least capsid proteins (penton-base, hexon), proteins responsible for cell binding (fiber protein), and proteins involved in adenovirus replication. This difference in tropism and capsid protein among serotypes has led to the many research efforts aimed at redirecting the adenovirus tropism by modification of the capsid proteins
