Formula (I) Wherein, R 1 represents a lower alkyl such as a hydrogen atom, substituted or unsubstituted,(Wherein, A 1 -A 2 -A 3 -A 4 and R 5 3, R 4 R is lower alkyl such as unsubstituted hydrogen atom, the same or different and each N = CR 3 -CR 4 = CR 5 represents and etc.) representing the, Q represents a phenylene substituted or unsubstituted, T is neutrophilic containing salt as an active ingredient or its pharmaceutically acceptable bicyclic heterocyclic compound represented by the formula: represents substituted or unsubstituted lower alkyl, aroyl, etc. substituted or unsubstituted I will provide a therapeutic agent, and the like, and / or prevention of inflammatory diseases.式(I)[式中、R1は水素原子、置換もしくは非置換の低級アルキル等を表し、A1-A2-A3-A4はN=CR3-CR4=CR5(式中、R3、R4及びR5は同一または異なって水素原子、置換もしくは非置換の低級アルキル等を表す)等を表し、Qは置換もしくは非置換のフェニレン等を表し、Tは置換もしくは非置換の低級アルキル、置換もしくは非置換のアロイル等を表す]で表される二環性複素環化合物またはその薬理学的に許容される塩を有効成分として含有する好中球性炎症疾患の予防及び/または治療剤等を提供する。
