The invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein R1 is -NR7(CO)R11 R2 is aryl, heteroaryl, fused aryl-C3-6-heterocycloalkyl or fused heteroaryl-C3-6- heterocycloalkyl, each of which is optionally substituted each R7 is selected from hydrogen, C1-6-alkyl and C3-7-cycloalkyl, wherein said C1-6-alkyl is optionally substituted by one or more halogens each R1, is independently selected from C1-6-alkyl, C3-7-xycloalkyl, C1-6alkyl-C3-7-cycloalkyl, C^-heterocycloalkyl, aryl and heteroaryl, each of winch may be optionally substituted. Further aspects of the invention relate to harmaceutical compositions comprising the same, and methods for treating or preventing a disorder selected from cancer, septic hock, Primary open Angle Glaucoma (POAG), hyperplasia, rheumatoid arthritis, psoriasis, artberosclerosis, retinopathy, os-eoarthritis, endometriosis, chronic inflammation and Alzheimer"s disease. Another aspect of the invention relates to the use of a compound as described above in the preparation of a medicament for the prevention or treatment of a disorder caused by, associat-d with or accompanied by any abnormal kinase activity, wherein the kinase is selected from TBK1, ERK8, CDK2, MARIO, ESI, VEG-FR, IKKepsilon and combinations thereof.
