Kyriacos C. NICOLAOU,Dionisios VOURLOUMIS,Jun YIN,Rohan ERANDE,Debashis MANDAL,Phillipp KLAHN
申请号：
US15553674
公开号：
US20180127463A1
申请日:
2016.02.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, and A1 are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
