NICOLAOU, KYRIACOS C.,VOURLOUMIS, DIONOSIOS,YIN, JUN,ERANDE, ROHAN,MANDAL, DEBASHIS,KLAHN, PHILIPP
申请号：
CA2977589
公开号：
CA2977589A1
申请日:
2016.02.25
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, and A1 are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
