An IL-6 production inhibitor which comprises rhinacanthin C alone as an active ingredient and inhibits IL-6 production in microglia. An anti-inflammatory agent which comprises rhinacanthin C alone as an active ingredient and inhibits IL-6 production in microglia to thereby prevent or suppress inflammation in the central nervous system. An anti-neurodegenerative disease agent or an anti-neuropsychiatric disease agent which comprises the IL-6 production inhibitor or anti-inflammatory agent as described above as an active ingredient. A medicine or a food which comprises the IL-6 production inhibitor, anti-inflammatory agent, anti-neurodegenerative disease agent or anti-neuropsychiatric disease agent as described above. According to the present invention, the IL-6 production inhibitor, anti-inflammatory agent, anti-neurodegenerative disease agent, anti-neuropsychiatric disease agent, medicine and food each using rhinacanthin C, which is clarified as having an inhibitory effect on IL-6 production in microglia, can be provided.一種IL-6產生抑制劑，含有僅以白鶴靈芝醌C當作有效成分，抑制微膠細胞中的IL-6的產生。而且，一種抗炎劑，含有僅以白鶴靈芝醌C當作有效成分，藉由抑制微膠細胞中的IL-6的產生預防或抑制中樞神經系統的發炎。而且，一種抗神經退化性疾病劑或抗精神神經疾病劑，含有以上述IL-6產生抑制劑或抗炎劑當作有效成分。進而一種醫藥品或食品，含有上述之IL-6產生抑制劑、抗炎劑、抗神經退化性疾病劑或抗精神神經疾病劑。 依照本發明，可提供一種使用抑制微膠細胞中的IL-6的產生很明顯的白鶴靈芝醌C之IL-6產生抑制劑、抗炎劑、抗神經退化性疾病劑、抗精神神經疾病劑、醫藥品及食品。
