the present invention relates to a docosahexaenoic acid ester with an alcohol chosen among the group-B vitamins or provitamins, advantageously comprised by: nicotinyl alcohol of the following formula:, panthenol of the following formula:and inositol of the following formula:or with isosorbide of the following formula:or isosorbide mononitrate of the following formula:.It also relates to a method of preparation of same, a pharmaceutical composition comprising same and the use of same in the treatment or prevention of cardiovascular disease, in particular auricular fibrillation.本發明係有關於一種二十二碳六烯酸酯,具有一擇自於該維生素B群或維生素原中之醇類,較佳地包含有:菸醇,該化學式如下:,泛醇,該化學式如下:及肌醇,該化學式如下:,或具有異山梨醇,該化學式如下:或異山梨醇單硝酸酯,該化學式如下:。其亦有關於製備包含有該物之一藥學組成物之一方法,並使用該物於治療或預防心血管疾病,特別是心房肌纖維顫動。
