A composition for oral administration of a bioactive agent to aquatic or terrestrial species includes particles each of which includes a bioactive agent dispersed in oil droplets, the oil droplets being dispersed in a matrix including an enteric coating polymer, wherein the particles each further include a mucoadhesive polymer. Methods of making and using the composition are also provided.生物活性劑之經口投與水棲或陸棲物種的組成物包含粒子,各粒子包含分散於油滴中之生物活性劑,所述油滴分散於包含腸溶性塗佈聚合物之基質中,其中所述粒子各自更包含黏膜黏著性聚合物。亦提供製造及使用所述組成物之方法。