3,4-二氫吡咯并[1,2-A]吡-2,8(1H)-二碳醯胺衍生物及其製備與治療用途农业专利-农业学术服务平台

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3,4-二氫吡咯并[1,2-A]吡-2,8(1H)-二碳醯胺衍生物及其製備與治療用途

专利权人:: SANOFI

发明人:: COTE DES COMBES, SYLVAIN,柯特　德斯　康柏斯　史尔文,柯特　德斯　康柏斯　史爾文,FROISSANT, JACQUES,佛洛山特　贾奎斯,佛洛山特　賈奎斯,GIBERT, JEAN-FRANCOIS,吉勃特　珍　法兰克斯,吉勃特　珍　法蘭克斯,MARGUET, FRANK,玛格特　法兰克,瑪格特　法蘭克,PACAUD, CHRISTOPHE,派可得　克里斯多夫,派可得　克里,柯特德斯康柏斯史尔文,柯特德斯康柏斯史爾文,佛洛山特贾奎斯,佛洛山特賈奎斯,吉勃特珍法兰克斯,吉勃特珍法蘭克斯,玛格特法兰克,瑪格特法蘭克,派可得克里斯多夫,派可得克里

申请号：: TW100119696

公开号：: TW201202248A

申请日:: 2011.06.03

申请国别(地区):: TW

年份:: 2012

代理人:

摘要：: Compounds corresponding to the general formula (I)in which R2 represents a group C1-10-alkyl, C3-10-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyl-C3-7-cycloalkyl, C3-7-cycloalkyl-C3-7-cycloalkyl, C1-6-alkylthio-C-1-10-alkyl, C1-6-alkoxy-C1-10-alkyl, hydroxy-C1-10-alkyl, hydroxy-C1-6-alkyl-C3-7-cycloalkyl-C1-6-alkyl, hydroxy-C3-10-cycloalkyl, C1-10-fluoroalkyl or C3-10-fluorocycloalkyl； an optionally substituted heterocyclic group； a group C1-10-alkyl substituted with an optionally substituted heterocyclic group； X6 represents a group chosen from hydrogen, fluorine, chlorine and bromine atoms or a group C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyi, C1-6-fluoroalkyl or cyano； and R7 represents an aryl group such as phenyl or naphthyl, optionally substituted with one or more substituents, in the form of the base or of an acid-addition salt. Therapeutic use.本發明係關於對應於通式(I)之化合物其中R2代表基團C1-10-烷基、C3-10-環烷基、C3-7-環烷基-C1-6-烷基、C1-6-烷基-C3-7-環烷基、C3-7-環烷基-C3-7-環烷基、C1-6-烷硫基-C-1-10-烷基、C1-6-烷氧基-C1-10-烷基、羥基-C1-10-烷基、羥基-C1-6-烷基-C3-7-環烷基-C1-6-烷基、羥基-C3-10-環烷基、C1-10-氟烷基或C3-10-氟環烷基；視情況經取代之雜環基；經視情況經取代之雜環基取代之基團C1-10-烷基；X6代表選自氫、氟、氯及溴原子之基團或基團C1-6-烷基、C3-7-環烷基、C3-7-環烷基-C1-6-烷基、C1-6-氟烷基或氰基；且R7代表視情況經一或多個取代基取代之芳基，例如苯基或萘基，其呈鹼或酸加成鹽形式。本發明亦係關於治療用途。