High affinity SIRP-alpha reagents

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专利权人:

The Board of Trustees of the Leland Stanford Junior University

发明人:

Ring, Aaron Michael,Garcia, Kenan Christopher,Weiskopf, Kipp Andrew,Levin, Aron M.,Weissman, Irving L.

申请号：

AU2013209736

公开号：

AU2013209736C1

申请日:

2013.01.17

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

High affinity SIRP-α reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein； and (ii) have an increased affinity for CD47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity SIRPα reagent, which blocks the physiological binding interaction between SIRPα and its ligand CD47.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/