The Board of Trustees of the Leland Stanford Junior University
发明人:
Aaron Michael Ring,Kenan Christopher Garcia,Kipp Andrew Weiskopf,Aron M. Levin,Irving L. Weissman
申请号：
US15912471
公开号：
US20180195054A1
申请日:
2018.03.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
High affinity SIRP-α reagent are provided, which (i) comprise at least one amino acid change relative to the wild-type protein； and (ii) have an increased affinity for CD47 relative to the wild-type protein. Compositions and methods are provided for modulating phagocytosis in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity SIRPα reagent, which blocks the physiological binding interaction between SIRPα and its ligand CD47.
